Islet Amyloid Polypeptide—Hen or EGG in Type 2 Diabetes Pathogenesis?
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چکیده
منابع مشابه
Islet Amyloid Polypeptide is not a Target Antigen for CD8+ T-Cells in Type 2 Diabetes
Background: Type 2 diabetes (T2D) is a chronic metabolic disorder in which beta-cells are destroyed. The islet amyloid polypeptide (IAPP) produced by beta-cells has been reported to influence beta-cell destruction. Objective: To evaluate if IAPP can act as an autoantigen and therefore, to see if CD8 + T-cells specific for this protein might be present in T2D patients. Methods: Peripheral blood ...
متن کاملislet amyloid polypeptide is not a target antigen for cd8+ t-cells in type 2 diabetes
background: type 2 diabetes (t2d) is a chronic metabolic disorder in which beta-cells are destroyed. the islet amyloid polypeptide (iapp) produced by beta-cells has been reported to influence beta-cell destruction. objective: to evaluate if iapp can act as an autoantigen and therefore, to see if cd8 + t-cells specific for this protein might be present in t2d patients. methods: peripheral blood ...
متن کاملIslet amyloid polypeptide, islet amyloid, and diabetes mellitus.
Islet amyloid polypeptide (IAPP, or amylin) is one of the major secretory products of β-cells of the pancreatic islets of Langerhans. It is a regulatory peptide with putative function both locally in the islets, where it inhibits insulin and glucagon secretion, and at distant targets. It has binding sites in the brain, possibly contributing also to satiety regulation and inhibits gastric emptyi...
متن کاملRecent Insight in Islet Amyloid Polypeptide Morphology, Structure, Membrane Interaction, and Toxicity in Type 2 Diabetes
1Laboratoire des Biomolécules, Sorbonne Universités, UPMC Université Paris 06, 4 place Jussieu, 75005 Paris, France 2Département de Chimie, Ecole Normale Supérieure-PSL Research University, 24 rue Lhomond, 75005 Paris, France 3UMR 7203, Laboratoire des Biomolécules, CNRS, 75005 Paris, France 4Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Av...
متن کاملPrevalence and clinicopathological characteristics of islet amyloid in chinese patients with type 2 diabetes.
Islet amyloid has been suggested to be an important link between insulin resistance and beta-cell dysfunction in type 2 diabetes. To investigate the prevalence and clinicopathological characteristics of islet amyloid, we examined consecutive autopsies of 235 Chinese patients with type 2 diabetes and 533 nondiabetic subjects. Islet amyloid deposits were identified using Congo red staining and qu...
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ژورنال
عنوان ژورنال: Acta Oncologica
سال: 1993
ISSN: 0284-186X,1651-226X
DOI: 10.3109/02841869309083904